Chemical Aspects of Premature Ejaculation

Neurotransmitter Imbalance
Neurotransmitter imbalance causes premature ejaculation, nerve disorders, hypersensitivity, anxiety, depression and other mental illnesses. Mental illness is under diagnosed through out the world. A study showed that 42% lifelong premature ejaculators has ADHD.

Neurotransmitters controls your arousal, erection and orgasm etc. Each one of us has different levels of these neurotransmitters and this determines our general behavior and personal traits. Neurotransmitters are used to transport different messages to our body organs by the central nervous system.

There are excitory neurotransmitters like histamine and dopamine. High levels of these causes over excitement, over arousal, over sensitivity and over activity.

There are inhibitory transmitters like serotonin and GABA. Those who are high in these, last long and stay relaxed and calm and enjoy good sleep. Those who are low in inhibitory transmitters have sensitive and inflamed nerves and penis.

Normally, the balance of neurotransmitters is determined by the body metabolism through a complex feedback mechanism.

A. The first transmitter is serotonin, its deficiency causes premature ejaculation, anxiety and depression etc. That is why, the first thing a doctor prescribes is an SSRI drug.
Recreational drugs and weeds including opiates etc., also increase the serotonin. Exercising and working out muscles also increase the serotonin.

Supplements: Griffonia Seed Extract or 5-HTP, St. Johns Wort, L-Tryptophan, Ashwagandha, Vitamin B-Complex.

B. GABA is the second most important neurotransmitter. Lack of it makes the nerves hyperactive and causes premature ejaculation, insomnia, restless legs syndrome, nerve control, motor control etc. Severe deficiency of it causes epilepsy. If drinking alcohol makes you last long, increasing GABA will most probably help you last long. Alcohol increases GABA in the brain temporarily.

Supplements: Glutamine, Green tea or L-Theaning, St. John's Wort, Vitamin B6, Magnesium, Passion Flower, Ashwagandha, Valerian, Kava-Kava. Almonds, Walnuts are also good foods.

C. High levels of histamine causes premature ejaculation, anxiety, over stimulation, aggressiveness, compulsive and a racing brain, high libido, allergies, and low muscle tone. Easy orgasm and high libido is a major symptom of histamine (histadelia). A saliva test is available for testing high levels of histamine.
According to "The Amino Revolution" book, premature ejaculation in younger males is due to high levels of histamine.
Dr. Pfeiffer mentioned premature ejaculation as a symptom of histadelia in his book (page 155). This topic is worth reading. On page 160, he prescribes following to lower the histamine:
In summary, the treatment program for histadelia is:
1. Vitamin C 1.0 gm AM & PM
2. Vitamin B-6 to normal dream recall
3. DL-Methionine 500 to 1000 mg AM & PM
4. Calcium salt 500 mg AM & PM
5. Phenytoin (Dilantin) 100 mg AM & PM
6. Low protein diet
7. Avoid multivitamins and folic acid

Here is another document which describes to lower histamine levels using Methionine, L-Arginine, Vitamin C, Vitamin B6 and calcium etc.

Here is a list of histamine lowering foods. Some of these are often found in premature ejaculation supplements.
Sulfur rich foods (like ginger, garlic, onions, turmeric, eggs, cauliflower, broccoli) are good to reduce histamine. Quercetin, Nyquil, butterbur also lowers histamine.
Most effective supplements are MSM, SAMe, Methionine, L-Arginine/Citrulline, Calcium, Vitamin-C, inositol, TMG, and zinc.
Avoid: Folic Acid, Alcohol, histadine, sugar
Delayed ejaculators are given histadine to increase histamine levels.

D. Dopamine is a pleasure and motivation neurotransmitter.
High levels cause over excitement and over arousal and therefore cause premature ejaculation. If your refractory period is low, then you are high in dopamine.
Anxiety, psychosis, addiction, compulsion, gambling, aggression and unhealthy risk taking are some symptoms associated with increased levels of dopamine.

Low levels of dopamine cause Parkinson's disease etc. In this case Macuna Prurens is used to increase dopamine.

E. Nitric Oxide is also very important to relax the smooth muscles and calm the nerves. L-Arginine, Citrulline, Ashwagandha, pomegranate, watermelon is good for increasing nitric oxide production.

Mineral Imbalance
Mineral Imbalance is another important factor in premature ejaculation. It greatly affects the neurotransmitter balance.
Zinc, Magnesium, Potassium, Selenium, Copper, Manganese, Calcium etc., are also very important. These are often included with a multi mineral tablet.
Almonds, nuts are important for healthy nervous system and contain balanced minerals like magnesium, potassium and calcium etc.

Summary:
If you are making slow progress with pelvic floor exercises and edging etc, there is no harm in trying some of the above herbal and food supplements. These are just foods and not prescription drugs.

What a typical supplement for premature ejaculation looks like? It contains ingredients to lower histamine levels and increase serotonin, GABA and nitric oxide.